News

April 2016-March 2017

  • Bhanudas Dasari, PhD (July 2015, University of Hyderabad), after working with Sai Advantium, Hyderabad (for a brief period) seeking an industrial experience, joined as a post-doctoral fellow at the Institut Curie Research Centre, Paris, France.
  • Ravi Kumar Jimmdi, PhD (Feb 2015, University of Hyderabad), after working with Sai Advantium, Hyderabad (for a brief period) seeking an industrial experience, won through an open competition, a post-doctoral fellowship, in Belgium.
  • Srinivas Jogula PhD (Jan 2016, University of Hyderabad), came back to India recently (Jan 2017), after completing his 1 year post-doctoral fellow tenure in Japan. Presently, he is giving job interviews with India pharma companies.
  • Mahender Khatravath, PhD (June 2016, University of Hyderabad), defended his thesis successfully. He won the DST SERB National Post-Doctoral Fellowship to work with Dr. D. S. Reddy, National Chemical Laboratory, Pune.
  • Naveen Kumar Mallurwar, PhD (October 2016, University of Hyderabad), defended his thesis successfully. Currently, he is working in the group as a Research Associate on a project, funded by the "Drugs from Sea" program.
  • Jagan Gaddam PhD thesis (to be submitted by Feb end, 2017) to University of Hyderabad.
  • Madhu Aeluri is now working in the group as a Research Associate (jointly supervised by Dr. Satish Srinivas Kitambi, Karolinska Inst, Sweden) after completing his industrial tenure at the GVK Bio Hyderabad. He will be moving to Karolinska in June 2017.

See our recently published/submitted research articles

Peer Reviewed Publications
  • Stereoselective Synthesis of C27-C35 Eribulin Fragment for Building A Macrocyclic Diversity. Saidulu Konda, Naveen Kumar Mallurwar, Mahender Khatravath, Pallavi Rao, Shivashankar Sripally, Javed Iqbal and Prabhat Arya. Synthesis (special topic: target oriented synthesis of complex molecules) 2016, 48, 1663-1683.
  • Macrocyclic Toolbox from Epothilone Fragment Identifies A Small Molecule Showing Molecular Interactions with Actin and Novel Promoters of Apoptosis in Patient-derived Brain Tumor Cells. Bhanudas Dasari, Jagan Gaddam, Temesgen Fufa, Madhu Aeluri, Girdhar Singh Deora, Frank Gaunitz, Satish Srinivas Kitambi and Prabhat Arya. Asian JOC. 2016, 5, 976-980
  • A Macrocyclic Small Molecule Having Cyclosporin A-Like Activity Prevents the Induction of Mitochondrial Permeability Transition and Cytochrome c. Govardhan K. Shroff, Mithila Sawant, Ravikumar, Jimmidi, Girdhar Singh Deora, Sandhya Sitasawad, Kiranam Chatti, Prabhat Arya and Prasenjit Mitra. 2016, submitted.
  • Synthesis and Biological Evaluation of Rapamycin-derived, Next Generation Small Molecules. Shiva Krishna Reddy Guduru and Prabhat Arya. 2016, submitted.
  • A Modular Approach to Building 17- and 18-Membered Macrocyclic Diversity from Eribulin C14-C21 Fragment. Naveen Kumar Mallurwar, Saidulu Konda, Mahender Khatravath, Pallavi Rao, Shivashankar Sripally, Javed Iqbal and Prabhat Arya. 2016, submitted.
  • Synthesis of C1-C10 Eribulin Fragment and its Analogues for Building A Diverse Set of Macrocycles. Mahender Khatravath, Saidulu Konda, Naveen Kumar Mallurwar, Pallavi Rao, Shivashankar Sripally, Javed Iqbal and Prabhat Arya. 2016, submitted.
  • Geldanamycin-Inspired Compounds Induce Direct Trans-differentiation of Human Mesenchymal Stem Cells to Neurons. Srinivas Jogula, Anand Soorneedi, Jagan Gaddam, Srinivas Chamakuri, Girdhar Singh Deora, Ranjith Kumar Indarapu, Subhadra Dravida, and Prabhat Arya. 2017, submitted.
  • Small molecule inhibition of pro-apoptotic Bax and Bak promotes long term cell survival and protects primary neurons from excitotoxicity. Xin Niu, Hetal Brahmbhatt, Philipp Mergenthaler, Zhi Zhang, Jing Sang, Wibke Diederich, Eve Wong, Weijia Zhu, Justin Pogmore, Jyoti P. Nandy, Maragani Satyanarayana, Ravi K. Jimmidi, Prabhat Arya, Brian Leber, Jialing Lin, Carsten Culmsee, Jing Yi and David W. Andrews. 2017 submitted.

Book Chapters
  • Building a Natural Product-Inspired, Macrocyclic Toolbox for Protein-Protein Interactions and Signaling Pathways. Madhu Aeluri, Bhanudas Dasari, Jagan Gaddam, Naveen Kumar Mallurwar and Prabhat Arya, Dr Reddy’s Institute for Life Sciences, University of Hyderabad for a Book, Title: Practical Medicinal Chemistry with Macrocycles: Design, Synthesis and Case Studies, Eric Marsault and Mark L. Peterson, editors, 2017, in press

Patents
  • Novel Geldanamycin-inspired compounds as the direct converters of human / patient mesenchymal stem cells to neurons and method of its preparation thereof. Subhadra Dravida, Ranjit Kumar, Anand Soorneedi, Jogula Srinivas and Prabhat Arya. India and US provisional patent submitted, 2016.
  • Neopeltolide-inspired, novel macrocyclic small molecules as the trans-differentiators of human mesenchymal stem cells to neuronal progenitors and the methods of preparation thereof. Subhadra Dravida, Ranjit Kumar, Anand Soorneedi, Jagan Gaddam and Prabhat Arya. India and US provisional patent submitted, 2016.
  • Design and synthesis of heterocyclic-derived macrocyclic compounds and their application as the direct converters of human mesenchymal stem cells to neurons. Subhadra Dravida, Ranjit Kumar, Anand Soorneedi, Jagan Gaddam, Madhu Aeluri and Prabhat Arya. India and US provisional patent, submitted, 2017.
  • Design and synthesis of furan ring-derived macrocyclic compounds and their utility as the trans-differentiators of human mesenchymal stem cells to neuronal progenitors. Subhadra Dravida, Ranjit Kumar, Anand Soorneedi, Ravi Kumar Jimmidi, Saidulu Konda, Naveen Kumar Mullurwar, and Prabhat Arya, India and US provisional patent, submitted, 2017.

Invited lectures by Prabhat
  • Keynote Speaker, SelectBio MedChem 2015 India, International conference on medicinal chemistry, Sept 10-11, 2015
    Title: Building New Research Models for Next Generation Drug Discovery
  • National Med Chem Meeting, SV University, Tirupati, Telanagna, Sept 14-15, 2015
    Title: The Impact of Modern Organic Synthesis in Next Generation Drug Discovery
  • Keynote Speaker, International Conference on "Clinical Challenges in Oncology and Innovations towards its Therapeutics" , February 18-20, 2016, Rajiv Gandhi Proudyogiki Vishwavidyalaya (RGPV), Bhopal, India
    Title: Building New Research Models for Next Generation Drug Discovery
  • Advances in Cancer Therapeutics (ACT)-2016, CSIR-IICT Hyderabad, April 4 and 5, 2016
    Title: Going in for Undruggable Targets
  • Keynote Speaker, National Conference on "Emerging Trends in Drug Discovery and Green Chemistry", Telangana University, Nizamabad, Telangana, April 12, 2016
    Title: Building New Research Models for Next Generation Drug Discovery
  • Session Chair, Invited Speaker, XI ISBA Conference 2016 and Maha Innovation Awards 2016, 10th to 12th September in Mumbai
  • Invited Speaker, Invitation to deliver a Talk for 2nd International Conference on Translational Research: Applications in Human Health & Agriculture, KIIT University, Bhubaneswar, Oct 14-16, 2016
    Title: Integration of Translational Organic Synthesis with Patient-derived, Tumor Xenograft in Cancer Drug Discovery
  • IISER Thiruvananthapuram, Nov 15, 2016
    Title: The Integration of Stereoselective Organic Synthesis (SOS) with Clinically-relevant Signaling Pathways: An Exciting Journey
  • University of Hyderabad, School of Life Sciences - Students Science Club, Hyderabad
    Title: Building New Research Models in Drug Discovery Arena: A Tough Integration of Clinically Relevant Signaling Pathways with Translational Small Molecules. Nov 30, 2016.

Recent Grants Funded
  • Agency: Canada-Israel Joint Initiative, Grant Title: Chemistry and Biology of Protein Tyrosine Phosphatases, Name of PI: Michel Tremblay, Team Members: Ari Elson, Weismann Institute, Israel and Prabhat Arya, DRILS Hyderabad, Period 2016-2019 (3 years)
  • Agency: Karolinska Institute, Sweden, Title of Grant: Expertise in Advanced Organic Synthesis and Med Chem, Name of PI: Prabhat Arya, Period: 2016-2017 (1 year)

Sports, Misc
  • Prabhat (along with Subhadra) went for 2 days trekking - Triund Mountain, McLeod Ganj, Dharamsala, Himachal Pradesh http://www.triund.in/triund/TRIUND.html (Nov 2016)
  • Prabhat went for a long distance cycling tour - from Gachibowli Hyderabad to outskirts, 120 kms (covered in 6.0 hrs) (Jan 2017)

April 2015-March 2016

Congratulations! The following students from our group have successfully defended their PhD thesis and moved on for the next level challenges:
  • Bhanudas Dasari, PhD (Dec 2014), University of Hyderabad, Thesis title: Synthesis of Carbohydrate-based Macrocycles and Epothilone Fragment-Derived Hybrid Molecules. Currently, working as a Research Scientist with Sai Advantium, Hyderabad.
  • Saidulu Konda PhD (Jan 2016), University of Hyderabad, Thesis title: Stereoselective Synthesis of C27-C35 Eribulin Fragment and Related Macrocycles. Currently, working as Research Scientist with GVKBio Hyderabad.
  • Srinivas Jogula PhD (Jan 2016), University of Hyderabad, Thesis title: Sereoselective Synthesis of Ansamycin-Inspired Macrocycles and Macrocyclic Glycohybrids. Currently, working as a PDF in Japan.
  • Mahender Khatravath, PhD thesis submitted (Jan 2011-Feb 2016), University of Hyderabad, Thesis title: Stereoselective Synthesis of Sub-structures of Eribulin and Related Macrocyclic Compounds. Waiting for his thesis defence.
  • Naveen Kumar Mallurwar, PhD thesis submitted (April 2016), University of Hyderabad, Thesis title: Stereoselective Synthesis of Sub-structures of Eribulin (C14-C21 and C22-C28) and Related Macrocyclic Compounds. Waiting for his thesis defence.

See our recently published articles:
  • A Regio- and Stereocontrolled Dieckmann Approach to Treprostinil-Inspired, Polycyclic Scaffold For Building Hybrid Macrocycles. Srinivas Chamakuri, Srinivas J. and Prabhat Arya. ACS Comb. Sci. 2015, 17, 437-441.
  • A Macrocyclic Small Molecule Having Cyclosporin A-Like Activity Prevents the Induction of Mitochondrial Permeability Transition and Cytochrome c. Govardhan K. Shroff, Mithila Sawant, Ravikumar, Jimmidi, Girdhar Singh Deora, Sandhya Sitasawad, Kiranam Chatti, Prabhat Arya and Prasenjit Mitra. 2015, submitted.
  • Synthesis and Biological Evaluation of Rapamycin-derived, Next Generation Small Molecules. Shiva Krishna Reddy Guduru and Prabhat Arya. 2016, submitted.
  • Stereoselective Synthesis of C27-C35 Eribulin Fragment for Building A Macrocyclic Diversity. Saidulu Konda, Naveen Kumar Mallurwar, Mahender Khatravath, Pallavi Rao, Shivashankar Sripally, Javed Iqbal and Prabhat Arya. 2016, accepted for the journal, Synthesis, special issue on "target oriented synthesis of complex molecules".
  • A Modular Approach to Building 17- and 18-Membered Macrocyclic Diversity from Eribulin C14-C21 Fragment. Naveen Kumar Mallurwar, Saidulu Konda, Mahender Khatravath, Pallavi Rao, Shivashankar Sripally, Javed Iqbal and Prabhat Arya. 2016, submitted.
  • Synthesis of C1-C10 Eribulin Fragment and its Analogues for Building A Diverse Set of Macrocycles. Mahender Khatravath, Saidulu Konda, Naveen Kumar Mallurwar, Pallavi Rao, Shivashankar Sripally, Javed Iqbal and Prabhat Arya. 2016, accepted.
  • Building A Macrocyclic Toolbox from Epothilone Fragment Identifies Actin Binders and Novel Promoters of Apoptosis in Patient-derived Brain Tumor Cells. Bhanudas Dasari, Temesgen Fufa, Madhu Aeluri, Girdhar Singh Deora, Frank Gaunitz, Satish Srinivas Kitambi and Prabhat Arya. 2016, submitted.
  • Geldanamycin-inspired Macrocyclic Compounds Lead to Identify a New Family of HSP90 Binders. Srinivas Jogula, Srinivas Chamakuri, Sri Krishna Varma Penmetsa, Girdhar Singh Deora and Prabhat Arya. 2016, submitted.
  • . Small molecule inhibition of pro-apoptotic Bax and Bak promotes long term cell survival and protects primary neurons from excitotoxicity. Xin Niu, Hetal Brahmbhatt, Philipp Mergenthaler, Zhi Zhang, Jing Sang, Wibke Diederich, Eve Wong, Weijia Zhu, Justin Pogmore, Jyoti P. Nandy, Maragani Satyanarayana, Ravi K.Jimmidi, Prabhat Arya, Brian Leber, Jialing Lin, Carsten Culmsee, Jing Yi and David W. Andrews. 2016, submitted.

Our recently approved grant:

Agency: Ministry of Earth Sciences (MoES) / CSIR-CDRI; Title of Grant Latrunculin and Eribulin Sub-structures Derived Macrocyclic Toolbox; Name of PI: Prabhat Arya; Team Members: Kiranam Chatti, Biology Dept, DRILS Hyderabad; Period: 3 years


Prabhat was invited to speak at the following meetings:
  • 1st International Conference on Translational Research: From Basic Science to Clinical Application” at KIIT University, Bhubaneswar, India, 5-7th February, 2015
  • Keynote Speaker, SelectBio MedChem 2015 India, International conference on medicinal chemistry, Sept 10-11, 2015
  • National Med Chem Meeting, SV University, Tirupati, Telanagna, Sept 14-15, 2015.
  • Keynote Speaker, International Conference on "Clinical Challenges in Oncology and Innovations towards its Therapeutics", February 18-20, 2016, Rajiv Gandhi Proudyogiki Vishwavidyalaya (RGPV), Bhopal, India.
  • Advances in Cancer Therapeutics (ACT)-2016, CSIR-IICT Hyderabad, April 4 and 5, 2016.

May 2015

Upcoming Pre-PhD Seminars from two students:

May 15, Friday @ 11:30 am, DRILS Class Room
Srinivas Jogula
PhD Student (Arya Group)
Joining Date: Jan 2011
Title: Stereoselective Synthesis of Ansamycin-inspired Macrocyclic Compounds and C-Linked Carbohydrate-based Glycohybrids

May 22, Friday @ 11:30 am, DRILS Class Room
Saidulu Konda
PhD Student (Arya Group, initially worked with Professor Javed Iqbal)
Joining Date: Jan 2011
Title: Stereoselective Synthesis of C1-C10 Eribulin Fragment and Analogs for Building A Diverse Set of Macrocyclic Compounds

November 2014-March 2015

Congratulations! The following students successfully defended their PhD thesis submitted to the University of Hyderabad:
  • Madhu Aeluri (currently working at the GVKBio Hyderabad)
  • Srinivas Chamakuri (going to join Damian Young's lab at the Baylor College of Medicine as a PDF)
  • Ravikumar Jimmidi (currently working at the GVKBio Hyderabad)
  • Shiva Krishna Reddy Guduru (going to join Damian Young's lab at the Baylor College of Medicine as a PDF)

Bhanudas Dasari submitted his PhD thesis "Synthesis of Carbohydrate-based Macrocycles and Epothilone Fragment-Derived Hybrid Molecules" to the University of Hyderabad (December 2014)

See our recently published articles:
  • Rethinking Drug Discovery. Invited article for Magazine, Pharma Focus Asia. Subhadraw Dravida and Prabhat Arya. 2014, Vol 21, Nov Issue.
  • A Divergent Approach to Building Latrunculin Family-derived, Hybrid Macrocyclic Toolbox. M. Aeluri, M.; B. Dasari, P. Arya. Org. Lett. 2015, 17(3), 472-475.
  • Practical Stereoselective Synthesis of Eribulin Fragment toward Building a Hybrid Macrocyclic Toolbox. Ravkumar Jimmidi, Shiva Krishna Reddy Guduru and P. Arya. Org. Lett. 2015, 17(3), 468-471.
  • Stereoselective Synthesis of Rapamycin Fragment to Build a Macrocyclic Toolbox. Shiva Krishna Reddy Guduru, Ravikumar Jimmidi, Girdhar Singh Deora and Prabhat Arya. Org. Lett. 2015, 17(3), 480-483.
  • Selected Hybrid Natural Products as Tubulin Modulators. Invited mini-review article. Bhanudas Dasari, Ravikumar Jimmidi and Prabhat Arya. Eur. J. Med. Chem. 2015, 94, 497-508 (special issue on "novel chemistry for undruggable targets").
Our recently approved grant:
  • DST-SERB: Title: Hybrid Natural Products to Hunt for Functional Small Molecules, Prabhat Arya, PI, 2015-2018, 43.0 Lakhs
Prabhat was invited to speak at the following meetings
  • IUPAC’s International Symposium on Bio-Organic Chemistry, Indian Institute of Science Education and Research, Pune, India, January 11-15, 2015.
  • 1st International Conference on Translational Research: From Basic Science to Clinical Application” at KIIT University, Bhubaneswar, India, 5-7th February, 2015.

July - October 2014

Congratulations! The following students submitted their PhD thesis to the University of Hyderabad:

Madhu Aeluri
PhD Thesis Title: Synthesis of Natural Product-Inspired Macrocyclic Architectures and Hybrid Latrunculins
Thesis submitted in June 2014
At present, he is working at the GVKBio Hyderabad as a Research Scientist to gain some industrial experience

Srinivas Chamakuri
PhD Thesis Title: Synthesis of Amino-indoline Based Macrocycles and Treprostinil Inspired Hybrid Compounds
Thesis submitted in August 2014
He has accepted to work as a Post-doctoral Fellow with Professor Damian Young, Center for Drug Discovery Baylor College of Medicine, Houston

Ravikumar Jimmidi
PhD Thesis Title: A Divergent Approach to Benzofuran-inspired, Macrocycles and Eribulin Fragment-based Hybrid Compounds
Thesis submitted in August 2014
At present, he is working at the GVKBio Hyderabad as a Research Scientist to gain some industrial experienc

Shiva Krishna Reddy Guduru
PhD Thesis Title: A Divergent Approach to Tetrahydroquinoline-Based Macrocycles and Rapamycin Fragment-Derived Hybrid Molecules
Thesis submitted in October 2014
He has accepted to work as a Post-doctoral Fellow with Professor Damian Young, Center for Drug Discovery Baylor College of Medicine, Houston

Prabhat participated in a 66km bicycle "Freedom Ride" organized by The Atlanta Foundation, Hyderabad, August 15, 2014.

Prabhat gave a lecture, "Translational Chemical Biology: Exploring Novel Chemical Space to Hunt for Modulators of Signaling Pathways" at the National Chemical Laboratory, Pune, August 1, 2014.

Subhadraw Dravida and Prabhat Arya have written an article, "Re-thinking Drug Discovery" on invitation for Pharma Focus Asia magazine, due for the November issue.

Jan-June 2014

Four more students from our team will be presenting their final open door PhD thesis presentations:
  • Srinivas Chamakuri, June 25, 2014
  • Ravikumar Jimmidi, June 26, 2014
  • Shiva Krishna Reddy Guduru, June 27, 2014
  • Bhanudas Dasari, June 30, 2014
(all lectures start at 11:00 am, DRILS Class Room)

Madhu Aeluri, submitted his PhD thesis, entitled, "Synthesis of Natural Product-inspired Macrocyclic Architectures and Hybrid Latrunculins" to the University of Hyderabad Congratulations! June 2014

Finally, a special section on "Chemical Biology of Protein-Protein Interactions" for the journal, Chemical Reviews is out, and, see our article, entitled, "Small Molecule Modulators of Protein-Protein Interactions: Selected Case Studies". May 2014

Prabhat was invited to speak at the CHI Drug Discovery Chemistry Meeting, San Diego, April 22-24, 2014.

Prabhat was invited to speak at the RSC-Daiichi-Sankyo Meeting, "Overcoming the Bottlenecks in Drug Discovery and Development, Gurgaon, March 20 and 21, 2014

Prabhat organized one day drug discovery track at the BioAsia 2014 event in Hyderabad (Feb 18, 2014)

The following papers are published/submitted during this period:
  • Congratulations to Ravi and Goverdhan for this work! "The Prevention of Mitochondrial Membrane Permeabilization and Pancreatic -Cell Death by an Enantioenriched, Macrocyclic Small Molecule". Ravikumar Jimmidi, Govardhan K. Shroff, M. Satyanarayana, B. Ramesh Reddy, Jahnavi Reddy, Mithila A. Sawant, Sandhya L. Sitaswad, Prabhat Arya and Prasenjit Mitra. Eur. J. Org. Chem. 2014, 1151-56
  • Another article on Prabhat: Passion for Chemical Biology - Introduction to Dr. Prabhat Arya, Journal from Takshila Publishers, Chemical Biology and Cell Signalling, 2014, March 12, Vol 1, 1-3
  • Selected Hybrid Natural Products as Tubulin Modulators. Invited mini-review article. Bhanudas Dasari, Ravikumar Jimmidi and Prabhat Arya. Eur. J. Med. Chem. 2014, submitted (special issue on "novel chemistry for undruggable targets").
  • Building a Natural Product-inspired, Small Molecule Toolbox for Protein:Protein Interactions. Aeluri, M.; Chamakuri, S.; Dasari, B.; Guduru, S. R. K.; Jimmidi, R.; Jogula, S.; Mitra, P.; Arya, P. Acc. Chem. Res. 2014, submitted.

May - December 2013

  • Several research articles are published from our team - Congratulations to all, well done!

An Intramolecular Heck Approach to Obtain 17-Membered Macrocyclic Diversity and the Identification of Anti-angiogenesis Agent from Zebrafish Study. Madhu Aeluri, Jagan Gaddam, Devarakonda V. K. S. Trinath, Gayathri Chandrasekar, Satish Srinivas Kitambi, and Prabhat Arya.
Eur. J. Org. Chem. 2013, 19, 3955-3958

Tetrahydroquinoline-derived Macrocyclic Toolbox Identifies Novel Anti-angiogenesis Agents and Inhibitors of an Early Embryo Development in Zebrafish Assays. Shiva Krishna Reddy Guduru, Srinivas Chamakuri, Gayathri Chandrasekar, Satish Srinivas Kitambi, and Prabhat Arya
ACS Med. Chem. Lett., 2013, 4, 666-670

A Modular Approach to Build the Macrocyclic Diversity on Aminoindoline Scaffold Identifies Novel Anti-angiogenesis Agents from Zebrafish Assay. Srinivas Chamakuri, Shiva Krishna Reddy Guduru, Sreedhar Pamu, Gayathri Chandrasekar, Satish Srinivas Kitambi and Prabhat Arya
Eur. J. Org. Chem. 2013, 19, 3959-3964

Building a Macrocyclic Toolbox from C-Linked Carbohydrates Identifies Novel Anti angiogenesis Agents from Zebrafish Assay Srinivas Jogula, Bhanudas Dasari, Mahender Khatravath, Gayathri Chandrasekar, Satish Srinivas Kitambi, and Prabhat Arya
Eur. J. Org. Chem. 2013, 19, 5036-5040

Natural Products, Natural Product-Inspired and Synthetic Small Molecules as Modulators of Protein-Protein Interactions: Selected Case Studies. Madhu Aeluri, Srinivas Chamakuri, Bhanudas Dasari, Shiva Krishna Reddy Guduru,# Ravikumar Jimmidi, and Prabhat Arya (Invited Review Article for a mini-thematic issue on Chemical Biology of Protein: Protein Interactions, Guest Editor: Prabhat Arya) Chem. Rev. 2013, accepted for publication
(for a theme topic, July 2014 onwards: Chemical Biology of Protein:Protein Interactions; Guest Editor: Prabhat Arya)

The Prevention of Mitochondrial Membrane Permeabilization and Pancreatic -Cell Death by an Enantioenriched, Macrocyclic Small Molecule. Ravikumar Jimmidi, Govardhan K. Shroff, M. Satyanarayana, B. Ramesh Reddy, Jahnavi Reddy, Mithila A. Sawant, Sandhya L. Sitaswad, Prabhat Arya and Prasenjit Mitra Eur. J. Org. Chem. 2013, accepted for publication
  • Tony Pawson, a leading Canadian Cell Signaling researcher passed away on August 7, 2013. Tony was a true hero and showed a remarkable path to several youngsters in the cell signaling / protein-protein interaction arena. The Arya team deeply expresses the loss of an excellent role model and a senior colleague. We are going to miss you!
  • Prabhat finished 66 km (among the top 5 people) bicycle ride organized by the Hyderabad Bicycling Club, on August 15, 2013.

April 2013
The following two articles are accepted for publication:

A Modular Approach to Build the Macrocyclic Diversity on Aminoindoline Scaffold Identifies Novel Anti-angiogenesis Agents from Zebrafish Assay.
Srinivas Chamakuri, Shiva Krishna Reddy Guduru, Sreedhar Pamu, Gayathri Chandrasekar, Satish Srinivas Kitambi and Prabhat Arya.
Eur. J. Org. Chem. April 2013

An Intramolecular Heck Approach to Obtain 17-Membered Macrocyclic Diversity and the Identification of Anti-angiogenesis Agent from Zebrafish Study
Madhu Aeluri, Jagan Gaddama, Devarakonda V. K. S. Trinath, Gayathri Chandrasekar, Satish Srinivas Kitambi and Prabhat Arya.
Eur. J. Org. Chem. April 2013

March 15, 2013
The loss of a trailblazer innovator – Dr. Kallam Anji Reddy (http://en.wikipedia.org/wiki/Kallam_Anji_Reddy)
Dr. Anji Reddy, a true Indian trailblazer and a strong supporter of Innovation in Health Sciences Research, passed away on March 15, 2013. We at the Dr. Reddy’s Institute of Life Sciences salute our hero and the bond that he created with all of us will always remain active. A brief highlight of his selected contributions to science can be seen at this link: http://www.prabhatarya.org/presentations.html

Prabhat Arya
Innovation to Commercialization: Our Role Models
International Conference on Business Opportunities in Life Sciences, Modern College of Arts, Science and Commerce, Pune
Jan 28-30, 2012

Our recently published articles:

  • 14-Membered Macrocyclic Ring-derived Tool Box: The Identification of Small Molecule Inhibitors of Angiogenesis and an Early Embryo Development in Zebrafish Assays. Madhu Aeluri, Chinmoy Pramanik, Lakshindra Chetia, Naveen Kumar Mallurwar, Sridhar Balasubramanian, Gayathri Chandrasekar, Satish Srinivas Kitambi, and Prabhat Arya
    Org. Lett. 2013, 15(3), 436-439.
  • Macrocyclic Glycohybrid Tool Box Identifies Novel Anti-angiogenesis Agents from Zebrafish Assay. Bhanudas Dasari, Srinivas Jogula, Ramdas Borhade, Sridhar Balasubramanian, Gayathri Chandrasekar, Satish Srinivas Kitambi, and Prabhat Arya.
    Org. Lett. 2013, 15(3), 432-435.

Accepted for publication:

  • Tetrahydroquinoline-derived Macrocyclic Tool Box Identifies Novel Anti-angiogenesis Agents and Inhibitors of an Early Embryo Development in Zebrafish Assays. Shiva Krishna Reddy Guduru, Srinivas Chamakuri, Gayathri Chandrasekar, Satish Srinivas Kitambi, and Prabhat Arya
    March 2013

August 15, 2013
An upcoming cycling event: The Freedom Ride, 66 km
http://atlantafoundation.org/

April 5, Friday, 2013
DRILS Students’ Poster Presentation Day (an Open Door Event) - Download PDF

January 26, 2013
Prabhat participated in 100 km bicycle race in Hyderabad
http://atlantafoundation.org/